Moderate Calcific Aortic Valve Stenosis

Calcific aortic valve stenosis (CAVS) is a progressive disease characterized by calcification of the aortic valve and reduced blood flow from the heart. CAVS is the third most common cardiovascular condition in the U.S. and is known to lead to heart failure and death without intervention. With no approved therapy to treat the cause of this progressive disease, people with CAVS are left to "watchful waiting" as the current standard of care until the condition advances to the severe stage which requires surgery. There is critical unmet need for new therapies to treat the underlying cause of the disease and mitigate the need for valve replacement surgery, a challenge compounded by limited understanding of the biology driving valvular calcification and disease progression.